Skip to content

Caroline Le Guiner, PhD, TaRGeT Lab (UMR 1089 – INSERM, Nantes Université) Nantes, FRANCE

Team Leader – Translational Gene Therapy for Muscular Diseases Head of preclinical operations, Capacités Biotherapuetics Solutions

Caroline Le Guiner obtained her PhD thesis in 2003, within the specialty of Molecular Biology. She is currently a team leader in the TaRGeT lab (Translational Research for Gene Therapy) in Nantes, France (https://umr1089.univ-nantes.fr/en). She has more than 20 years of experience in translational research in viral vectors-based gene therapy, in particular for the treatment of rare muscle diseases using rAAV vectors. She has coordinated of large international networks, whose aim was the development of gene therapy products, especially for the treatment of Duchenne Muscular Dystrophy. She is an active member of the network that has been developed and characterised the DMDmdx rat model.
She has extensive experience in the development and implementation of strategies from the proof of concept phase through the start of Phase I/II clinical trials. She is familiar with experiments in animal models (including large animal models and GLP studies) from the design of the study plan to the compilation and analysis of all the results needed to understand the pharmacology and the pharmacokinetics of a therapeutic product.
She is also the head of preclinical operations at Capacités Biotherapeutics Solutions (CBS), the translational gene therapy business unit created a few years ago by the TaRGeT Lab in order to offer to industrial and academic partners access to the expertise of the Nantes’ gene therapy network.